Student Researchers' Society Topics

Co-Supervisor: Dr. KALOCSA, Luca

Endometriosis is a complex estrogen-dependent inflammatory disease that develops due to the ectopic presence of endometrial tissue. It affects 10-12% of women of reproductive age and is associated with severe pelvic pain and infertility. The disease is thought to involve complex sensory-vascular-immune interactions and mechanisms in its development and progression. However, the underlying processes and potential therapeutic approaches require further in vitro and in vivo research.

This project focuses on investigating the cellular and molecular processes of endometriosis using 2D and 3D cell cultures composed of human-immortalized endometriotic and stromal cell lines. We conduct a comprehensive in vitro pharmacological characterization of these cell models, assessing their viability, proliferation, and invasivion, as well as the effects of drugs targeting different molecular pathways on these parameters.

Co-Supervisor: GÖNTÉR, Kitti

In this topic we will study the effects of DMTS, an organic polysulphide, in a mouse model of anxiety and depression. Regarding the underlying mechanism, we investigate the endocannabinoid system. DMTS is likely to inhibit the main enzymes that degrade endocannabinoids by forming a disulfide bond with their cysteine side chains. Inhibition of these enzymes increases the endocannabinoid level in the CNS, reducing the effects of acute and chronic stress and the risk of depression.

Co-Supervisor: Dr. NAGY, András

We investigate the vitamin D content of commercial dietary supplements by HPLC method. 

We investigate the caffeine content of dietary supplements by HPLC method.

Co-Supervisor: Prof. Dr. HELYES, Zsuzsanna

Complex Regional Pain Syndrome (CRPS) is a multifactorial disease characterized by severe, persistent pain accompanied by abnormal hypersensitivity, swelling and autonomic alterations of the skin.  Although theethiology is unknown, immune response against sensory nerve-derived antigens and complex neuro-immune interactions are suggested to be involved in the development of this disease. The therapy is still an unresolved problem, the importance of central versus peripheral sensitization mechanisms and peripheral inflammatory processes is unclear. In this student research topic our aim is to investigate the possible autoimmun and neuro-immun backgrounds of the disease, especially the role of interleukin and its receptors in the mouse model of CRPS developed and characterized by our reserach group. 

Co-Supervisor: Dr. NAGY, András

In our study, we are going to use questionnaires to compare the mood and assess the mental health of individuals taking SGLT2 inhibitors versus those not using them. The study contributes to the understanding of potential effects of SGLT2 inhibitors on mood, which could lead to more comprehensive treatment approaches for individuals facing both diabetes and mood disorders.

Co-Supervisor: Dr. NAGY, András

In our study, we establish depression-like behavior in mice. We assess the behavior of mice treated with SGLT2 inhibitors versus control in tests characterizing anxiety and depression-like behavior. We collect brain samples and investigate neuronal activation of brain erase related to anxiety and depression with immunohistochemistry. The study contributes to the understanding of potential effects of SGLT2 inhibitors on mood, which could lead to more comprehensive treatment approaches for individuals facing both diabetes and mood disorders.